JaponicusDB - Gene - atb2 (SJAG_02509)

Gene: atb2 / SJAG_02509

Gene symbol

atb2

Product

tubulin alpha 2

Feature type

protein coding

Systematic ID

SJAG_02509

Product size

449 aa, 50.57 kDa

Genomic location

I,	874332-875681 (1350nt) coding start to stop
	874332-875681 (1350nt) including UTRs

Structure view loading ...

GO molecular function

Activities

Show details ...

+	structural constituent of cytoskeleton

Binding

Show details ...

+	GTP binding

GO biological process

Show details ...

+	cytoplasmic microtubule organization
+	mitochondrion distribution
+	mitotic spindle organization
+	nuclear division
+	nuclear migration by microtubule mediated pushing forces

View process term ancestry ...

GO cellular component

Show details ...

+	astral microtubule
+	cytosol
+	nucleus

Protein domains and features

Graphical view

View all protein features ...

Protein families and domains

Match ID	Source	Name	InterPro ID	Start	End
PF00091	Pfam	Tubulin/FtsZ, GTPase domain	IPR003008	3	213
PF03953	Pfam	Tubulin/FtsZ, 2-layer sandwich domain	IPR018316	263	392
cd02186	CDD	alpha_tubulin		2	435
PS00227	PROSITE_PATTERNS	Tubulin, conserved site	IPR017975	142	148
PS00228	PROSITE_PATTERNS	Beta tubulin, autoregulation binding site	IPR013838	1	4
SM00864	SMART	Tubulin/FtsZ, GTPase domain	IPR003008	49	246
SM00865	SMART	Tubulin/FtsZ, 2-layer sandwich domain	IPR018316	248	393
PR01162	PRINTS	Alpha tubulin	IPR002452	18	438
PR01161	PRINTS	Tubulin	IPR000217	10	408
G3DSA:3.30.1330.20:FF:000001	FUNFAM	Tubulin alpha chain		269	383
G3DSA:1.10.287.600:FF:000005	FUNFAM	Tubulin alpha chain		384	449
G3DSA:3.40.50.1440:FF:000008	FUNFAM	Tubulin alpha chain		1	268
SSF52490	SUPERFAMILY	Tubulin/FtsZ, GTPase domain superfamily	IPR036525	1	244
SSF55307	SUPERFAMILY	Tubulin/FtsZ, C-terminal	IPR008280	246	439
G3DSA:1.10.287.600	Gene3D	Tubulin, C-terminal	IPR023123	384	436
G3DSA:3.30.1330.20	Gene3D	Tubulin/FtsZ-like, C-terminal domain	IPR037103	269	383
G3DSA:3.40.50.1440	Gene3D	Tubulin/FtsZ, GTPase domain superfamily	IPR036525	1	268
PTHR11588	PANTHER	Tubulin	IPR000217	2	439
Coil	COILS	Coil		418	438

Domain organization at InterPro ...

No predicted trans-membrane domains

Protein properties

Molecular weight	50.57 kDa
Number of residues	449
Average residue weight	112 Da
Charge at pH 7	-18.46
Isoelectric point	4.79

Disease association

Show details ...

Filters:

(No slim terms)

+	amyotrophic lateral sclerosis type 22
+	keratoconus 9
+	lissencephaly due to TUBA1A mutation
+	macrothrombocytopenia, isolated, 2, autosomal dominant

Orthologs

Manually assigned orthologs

Ortholog species	Ortholog gene	Ortholog description	Reference
Homo sapiens	TUBA4A (HGNC:12407)	tubulin alpha 4a	Lock A et al. (2018)
Homo sapiens	TUBA3C (HGNC:12408)	tubulin alpha 3c	Lock A et al. (2018)
Homo sapiens	TUBA8 (HGNC:12410)	tubulin alpha 8	Lock A et al. (2018)
Homo sapiens	TUBA4B (HGNC:18637)	tubulin alpha 4b	Lock A et al. (2018)
Homo sapiens	TUBA1B (HGNC:18809)	tubulin alpha 1b	Lock A et al. (2018)
Homo sapiens	TUBA3E (HGNC:20765)	tubulin alpha 3e	Lock A et al. (2018)
Homo sapiens	TUBA1A (HGNC:20766)	tubulin alpha 1a	Lock A et al. (2018)
Homo sapiens	TUBA1C (HGNC:20768)	tubulin alpha 1c	Lock A et al. (2018)
Homo sapiens	TUBA3D (HGNC:24071)	tubulin alpha 3d	Lock A et al. (2018)
Schizosaccharomyces pombe	atb2 (SPBC800.05c)	tubulin alpha 2	Rhind N et al. (2011)
Saccharomyces cerevisiae	TUB1 (YML085C)	Alpha-tubulin more ...	Lock A et al. (2018)
Saccharomyces cerevisiae	TUB1 (YML085C)	Alpha-tubulin more ...	Herrero J et al. (2016)
Saccharomyces cerevisiae	TUB3 (YML124C)	Alpha-tubulin more ...	Lock A et al. (2018)
Saccharomyces cerevisiae	TUB3 (YML124C)	Alpha-tubulin more ...	Herrero J et al. (2016)

Ortholog prediction resources

Ensembl Fungal Compara	SJAG_02509	Alignments, gene trees, orthologs, families
Ensembl Pan-taxonomic Compara	SJAG_02509	Gene tree, orthologs

Transcript details

Show exon/intron/UTR positions

Key:

UTR

exon

mRNA SJAG_02509.1

tubulin alpha 2

Location: 874332-875681 (1350nt), chromosome I forward strand Product size: 449 aa, 50.57 kDa

Sequence

Show nucleotide sequence

Manually select residues

MREIISIHVGQAGTQIGNACWELYCLEHGIQPDGYMSPEAMEGKRDNGFSTFFSETGQGKYVPRSIYVDLEPNVIDQVRTGTYRNLFHPEQLITGKEDASNNYARGHYTVGKELVDDVVERIRRIADNCSGLQGFLVFHSFGGGTGSGFGALLLERLAMDYTKKSKLQFSVYPAPQVSTSVVEPYNSVLTTHATLDLADCTFMVDNESCYDICRRNLDIERPSYENLNRLIAQVVSSITASLRFEGSLNVDLAEFQTNLVPYPRIHFPLVTYAPIVSAAKAFHESNSVQEITNHCFEPYNQMVKCDPRAGRYMATCLLYRGDVIPRDVQAAVATIKAKRTIQFVDWCPTGFKIGICDRPPQHVANSEIAKVDRAVCMLSNTTAIAEAWSRLDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVGQDSMDADYMEEEY*

External references

GO annotation	QuickGO	B6K2P3	QuickGO Gene Ontology annotation viewer
GO annotation	AmiGO	SJAG_02509	GO Consortium browser
Interactions	STRING	B6K2P3	Network display of known and predicted interactions and functional associations
Sequence Resources	UniProtKB/SwissProt	B6K2P3	Protein database
Sequence Resources	NCBI	atb2	Query all NCBI databases
Sequence Resources	Ensembl	SJAG_02509	Genome browser
Orthologs	Ensembl Fungal Compara	SJAG_02509	Alignments, gene trees, orthologs, families
Orthologs	Ensembl Pan-taxonomic Compara	SJAG_02509	Gene tree, orthologs

Literature

Search PubMed for atb2

Sort by: Publication gene count | Authors | Year: Ascending / Descending

Details	Genes
Divergent strategies for controlling the nuclear membrane satisfy geometric constraints during nuclear division. Yam C et al. Curr Biol 2011 Aug 09;21(15):1314-9 PMID:21802294 Curated details ...	13
Ensembl comparative genomics resources. Herrero J et al. Database (Oxford) 2016;2016 PMID:26896847 details ...	2644
PomBase: The Scientific Resource for Fission Yeast. Lock A et al. Methods Mol Biol 2018;1757:49-68 PMID:29761456 details ...	4165
Comparative functional genomics of the fission yeasts. Rhind N et al. Science 2011 May 20;332(6032):930-6 PMID:21511999 details ...	4284